CHOLESTEROL BIOSYNTHESIS INHIBITOR CONTAINING TRICYCLIC COMPOUND HAVING SPIRO UNION AS EFFECTIVE COMPONENT

摘要

Orally administrable cholesterol biosynthesis inhibitors exhibiting potentserum cholesterol lowering effect, which inhibitors contain as the activeingredient tricyclic spiro compounds represented by the general formula (I) orsalts thereof: (I) wherein A is a 5- or 6-membered heterocyclic group or thelike; B is a single bond, carbonyl, or the like; D is hydrogen or the like; Xis nitrogen or the like; Y is oxygen, -NH-, or the like; Z is methylene,carbonyl, or the like; T is -SO2-, carbonyl, or the like; Q is a hydrocarbongroup or a heterocyclic group; l, m, and n are each an integer of 0 to 2, withthe proviso that both l and m are not 0 simultaneously; and r is 0 or 1.