The invention relates to human nucleotide sequences which occur as a result ofthe t(1;22)(p13;q13) chromosomal translocation event which is known to occuralmost invariable in young children with acute megakaryoblastic leukemia. Thetranslocation results in the formation of fusion genes which encode fusionproteins. The invention provides the nucleotide sequences of transcripts ofthe fusion genes and the amino acid sequences of the fusion proteins encodedthereby. Also provided are methods for detecting the t(1, 22) translocation,for identifying agents capable of binding to the fusion protein and foridentifying agents useful for treating patients with acute megakaryoblasticleukemia.
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