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Method and system for diagnosing pathology in biological samples by detecton of infrared spectral markers
Method and system for diagnosing pathology in biological samples by detecton of infrared spectral markers
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机译:通过检测红外光谱标记物诊断生物样品中病理的方法和系统
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摘要
A method and system for diagnosing pathology, such as carcinoma, in a biological sample identifies presence of pathology based on the existence of an infrared markers in the extracellular material, rather than cells, in the biological sample. In the case of breast cancer diagnosis, an effective marker is a baseline slope of a 1280 cm-1 band in the infrared spectra of connective tissue, with normal biopsy samples exhibiting a positive slope and cancerous samples showing a relatively flat baseline. Infrared spectroscopy, both microscopic and macroscopic, may be used to identify a sample region containing extracellular material and to collect infrared absorbance data, from which the existence of the pathology marker is determined.
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机译:用于诊断生物样品中的病理学例如癌症的方法和系统基于生物样品中细胞外材料而不是细胞中红外标记的存在来识别病理学的存在。在乳腺癌诊断的情况下,有效的标志物是结缔组织的红外光谱中1280 cm -1谱带的基线斜率,正常的活检样品显示正斜率,癌变样品显示相对平坦的基线。红外光谱,无论是微观的还是宏观的,都可以用来识别包含细胞外物质的样品区域,并收集红外吸收数据,从中可以确定病理标记的存在。
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