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RNase L activators and antisense oligonucleotides effective to treat telomerase-expressing malignancies
RNase L activators and antisense oligonucleotides effective to treat telomerase-expressing malignancies
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机译:RNase L激活剂和反义寡核苷酸可有效治疗表达端粒酶的恶性肿瘤
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摘要
The present invention relates to chimeric molecules comprising an oligonucleotide complementary to a region of the ribonucleotide component of telomerase attached to an activator of RNase L ("activator-antisense complex") which specifically cleaves the ribonucleotide portion of a telomerase enzyme. The present invention relates to methods of inhibiting telomerase enzymatic activity with activator-antisense complexes targeted to the RNA component of telomerase. The present invention further relates to methods of treating malignant neoplastic disease, wherein the malignant cells contain a telomerase activity that is necessary for the growth of the malignant cells.
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