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METHOD OF DETECTING NEOPLASTIC, HYPERPLASTIC, CYTOLOGICALLY DYSPLASTIC AND/OR PREMALIGNANT CELLULAR GROWTH OR PROLIFERATION
METHOD OF DETECTING NEOPLASTIC, HYPERPLASTIC, CYTOLOGICALLY DYSPLASTIC AND/OR PREMALIGNANT CELLULAR GROWTH OR PROLIFERATION
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机译:检测肿瘤,超塑性,细胞学上的发育不良和/或恶性细胞生长或增殖的方法
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摘要
Disclosed is a method of neoplastic, hyperplastic, cytologically dysplastic and/or premalignant cellular growth or proliferation in a human subject that involves collecting a sample from the human subject of a bodily substance, such as urine, blood, semen, saliva, mucus, feces, or cellular material, which contains the human subject's nucleic acid or protein. Expression and/or overexpression of nucleic acid or protein products of survivin gene, detected in the bodily substance, is diagnostic for the presence of neoplastic, hyperplastic, cytologically dysplastic and/or premalignant cellular growth or proliferation. Detection is through amplification by molecular biological techniques of survivin -specific nucleic acids and analysis of the amplification products, or by immunochemical assay for Survivin protein. Embodiments of the method are disclosed for detecting a neoplastic, hyperplastic, cytologically dysplastic and/or premalignant cellular growth or proliferation of the human urinary tract, such as a urinary tract neoplasm. Also disclosed are survivin gene-specific primers and probes, primer sets, and diagnostic kits containing them.
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