Photosensitiser containing phthalocyanine derivative for photodynamic therapy of tumours

摘要

Susceptible tumors are treated by first sensitizing them to incident electromagnetic radiation by of a compound of the formula: where M is a diamagnetic metal ion or a diamagnetic metal compound or silicon or a compound of silicon or is 2H; one H being bonded to each of the two nitrogen atoms depicted as being bonded to M at positions 29 and 31; R1 to R25 are the same or different and are independently selected from C1-C20, alkyl, C2-C20 alkenyl, X-O-Y, X2COOX1, x2COONR1R11 and H; wherein X and X2 are independently selected from a chemical bond, -(CH2)n- where n is an integer from 1 to 20 and -(CH2)aCH=CH(CH2)b where a and b are independently selected from integers 0-20 and a+b totals from 0 to 20; X1 is independently selected from C1-20 alkyl, C2-20 alkenyl and H; R1 and R11 are independently selected from H, C1-20 alkyl, C2-20 alkenyl; and Y is independently selected from C1-20 alkyl, C2-20 alkenyl and H; provided that not all R1-R25 are simultaneously H; and provided that not all R1-R25 are simultaneously n-alkoxy Thereafter tumors so treated are exposed to incident electromagnetic radiation which is absorbed by the compound (I).