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ENHANCED ANTI-CANCER AGENT DELIVERY TO SOLID TUMORS BY PRIMER COMPOUNDS
ENHANCED ANTI-CANCER AGENT DELIVERY TO SOLID TUMORS BY PRIMER COMPOUNDS
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机译:底漆化合物增强了向固体肿瘤中的抗癌剂输送
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摘要
Primer compositions for anti-cancer agent delivery to solid tumors in mammals, including man, are disclosed. The primer comprise a pharmaceutically acceptable agent which increases the intracellular levels of cyclic adenosine monophosphate (cAMP) in the normal connective tissue cells within solid tumors. Such an agent may be selected from any agents which increase the intracellular levels of cAMP, e.g. agents binding to and stimulating receptors at the connective tissue cell surface within tumors, and agents inhibiting cAMP phosphodiesterase. Local administration of the primer to the solid tumor area results in a lowering of the interstitial pressure. Further, an agent delivery system and a method for delivery of anti-cancer agents to solid tumors are described.
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