PROTEIN KINASE D INHIBITORS AND PROTEIN KINASE 2 INHIBITORS AS AGENTS FOR INHIBITING TUMOUR CELLS AND FOR STIMULATING ANGIOGENESIS

摘要

The invention relates to novel agents for influencing tumour growth or angiogenesis. Inhibitors of the protein kinase D and the protein kinase 2 which are associated with the COP9 signalosome (target complex) are used as effective agents for inhibiting tumour growth. Activators of the kinases associated with the target complex are used to activate angiogenesis. The inventive use of inhibitors of the kinases associated with the target complex is reflected in the triggering of apoptosis in tumour cells and in the inhibition of tumour angiogenesis and metastatic spread. The activators stimulate the formation of new blood vessels.