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METHODS OF PROLONGING TRANSPLANT SURVIVAL USING IMMUNOTOXINS AND COSTIMULATION BLOCKADE OF CD154 AND CD28
METHODS OF PROLONGING TRANSPLANT SURVIVAL USING IMMUNOTOXINS AND COSTIMULATION BLOCKADE OF CD154 AND CD28
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机译:利用免疫毒素和CD154和CD28的刺激封锁延长植株存活的方法
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摘要
The present invention provides a method of preventing chronic rejection of a transplant in a recipient, comprising administering to the recipient an immunotoxin, thereby reducing the recipient's T-cell population and administering to the recipient a costimulation blocker or a combination of costimulation blockers, thereby reducing a transplant-specific antibody response. Also provided is the method of preventing chronic rejection of a transplant in a recipient, further comprising administering an immunosuppressive agent to the recipient. The present invention also provides a method of reversing a late acute rejection of a transplant in a recipient having a transplant that has survived for a prolonged period of time using the method of preventing chronic rejection, comprising monitoring the recipient for an indicator of a delayed acute rejection response and administering to the recipient showing the indicator of the acute rejection response an immunotoxin, thereby reducing the recipient's T-cell population.
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