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ELECTRICALLY-MEDIATED ENHANCEMENT OF DNA VACCINE IMMUNITY AND EFFICACY IN VIVO
ELECTRICALLY-MEDIATED ENHANCEMENT OF DNA VACCINE IMMUNITY AND EFFICACY IN VIVO
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机译:体内DNA疫苗免疫和功效的电介导增强
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摘要
Electrically-mediated delivery technology has been applied to DNA vaccines and substantially higher immune responses have been achieved. In mice and rabbits vaccinated with DNA encoding HIV genes, when administered with constant electric current or constant electric voltage, up to twenty-fold higher immune responses were achieved compared with application of DNA vaccines alone. The increase was achieved under conditions of both constant current (iontophoresis) and constant voltage (electroporation).
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