UNCHARGED ANTISENSE OLIGONUCLEOTIDES TARGETED TO BACTERIAL 16S AND 23S RRNAS AND THEIR USES

摘要

The invention relates to compositions comprising oligomers antisense to bacterial 16S or 23S rRNA and capable of selectively modulating the biological activity thereof, and methods for their use. More particularly, the invention relates to antisense oligomers directed to 16S or 23S rRNA found in one or more particular bacteria, or generally conserved among bacteria in general, and to pharmaceutical compositions and methods of treatment comprising the same.