COMPOSITION HAVING ANTIMICROBIAL ACTIVITY FOR PROPIONIBACTERIUM ACNES AND INHIBITION ACTIVITY FOR 5ALPHA-REDUCTASE

摘要

PURPOSE: A composition having an antimicrobial activity for Propionibacterium acnes and an inhibition activity for 5alpha-reductase is provided, which composition has improved an antimicrobial activity for Propionibacterium acnes and treating and preventing activities for pimples. CONSTITUTION: The composition having an antimicrobial activity for Propionibacterium acnes and an inhibition activity for 5alpha-reductase comprises 0.005 to 10 wt.% of dried powder of Sophora Flavescens extract, in which the dried powder of Sophora Flavescens extract contains 0.05 to 12.9 wt.% of alkaloids as active ingredients for inhibiting the activity of 5alpha-reductase; the Sophora Flavescens extract is produced by dipping Sophora Flavescens in a solvent of at least one selected from purified water, methanol, ethanol, propanol, butanol, glycerol, propyleneglycol, 1,3-butyleneglycol, methylacetate, ethylacetate, benzene, hexane, diethylether and dichloromethane, and by evaporating or freeze-drying the Sophora Flavescens solution.