EVOLUTION AND USE OF ENZYMES FOR COMBINATORIAL AND MEDICINAL CHEMISTRY

摘要

The present invention provides a library of useful recombinant derivatized enzyme in vivo catalytic synthesis of organic molecules, including derivatives of the lead compound for pharmaceutical use. Derivatized recombinant enzyme catalyzes the reaction, such as Chemistry added to the vapor action, and which organic molecules are modified or replaced, or the action on the already existing. Using a recombinant enzyme library can be obtained when the enzyme catalyzing the formation of a complex organic molecule derivatives that can not otherwise be produced by using a naturally occurring enzyme.