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-442 Process for preparing -442

机译:-442准备过程-442

摘要

Known to as MKC-442 6- benzyl-1- (ethoxymethyl) discloses a method of producing 5-isopropyl uracil. The method of any using methods known in the activation Reformatsky reaction with zinc cyanide and benzyl-ethyl-2-bromo-3,3-dimethylethyl, including from propionitrile, Tate 2-isopropyl -3 - it includes a method for the synthesis of isopropyl β- keto ester such as butyrate-oxo-4-phenyl. Then ethyl-2-isopropyl-3-oxo-4-phenyl-butyrate and condensed with a thiourea as a way of two ways. First, ethyl 2-isopropyl-3-oxo-4-phenyl-butyrate and condensed with thiourea in a 2-base system in the presence of a solvent. Ethyl-2-isopropyl-3-oxo-4-phenyl-butyrate as a second method for condensing a thiourea is potassium -t- performed in the presence of butoxide to form the benzyl-isopropyl-thiourea, this step (B) The screen in the desulfurization. By alkylating the alkoxy benzyl isopropyl uracil resulting from any method to produce a MKC-442.
机译:称为MKC-442的6-苄基-1-(乙氧基甲基)公开了一种生产5-异丙基尿嘧啶的方法。与氰化锌和苄基乙基-2-溴-3,3-二甲基乙基(包括丙腈,Tate 2-异丙基-3)活化Reformatsky反应中已知的任何方法,包括合成异丙基的方法β-酮酸酯,例如丁酸酯-氧代-4-苯基。然后,将2-异丙基-3-氧代-4-苯基丁酸乙酯与硫脲缩合,以两种方式进行。首先,将2-异丙基-3-氧代-4-苯基丁酸乙酯在溶剂存在下于2-碱体系中与硫脲缩合。作为缩合硫脲的第二种方法的2-异丙基-3-氧代-4-苯基丁酸乙酯是在丁醇的存在下进行钾-t-形成苄基-异丙基-硫脲的步骤(B)。在脱硫中。通过将由任何方法得到的烷氧基苄基异丙基尿嘧啶烷基化以产生MKC-442。

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