Apicidin derivatives which inhibit histone deacetylase activity and cancer metastasis pharmaceutical compositions containing the same and use thereof

摘要

PURPOSE: Provided are Apicidin derivatives which inhibit cell growth selectively, histone deacetylase(HDAC) activity concentration dependently and MMP-2 activity effectively. And, provided are pharmaceutical compositions containing them and their use for the inhibition of HDAC and cancer metastasis. CONSTITUTION: Apicidin derivative is represented by the formula(1), wherein R is methoxy group; hydroxy group; C2-C6 dialkylamino group; C2-C6 linear or branched hydroxyalkyl; C3-C6 linear or branched dihydroxyalkyl group; C3-C6 alkoxyalkyl group; and substituted or unsubstituted 5 or 6 membered hetero cyclic compound including 1-3 of hetero atoms selected among unsubstituted or C1-C3 alkyl group substituted N, O, and S.