1,3,4-oxadiazole sulfamide derivative compound as histone deacetylase 6 inhibitor and pharmaceutical composition containing the same (1,3,4-Oxadiazole Sulfuride Derivative Compounds as Histone Deacetylase 6 Inhibitor) , And the Pharmaceutical Composition Comprising the same)

摘要

The present invention relates to a novel compound having histone deacetylase 6 (HDAC6) inhibitory activity, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, its use in the manufacture of a medicament for treatment, The present invention relates to a pharmaceutical composition containing the same, a treatment method using the composition, and a production method thereof. The novel compound according to the present invention, an optical isomer thereof, or a pharmaceutically acceptable salt thereof has a histone deacetylase 6 (HDAC6) inhibitory activity, and is an infectious disease, neoplasm. Endocrine, nutritional and metabolic diseases, mental and behavioral disorders, neurological diseases, eye and appendage diseases, cardiovascular diseases, respiratory diseases, gastrointestinal diseases, skin and subcutaneous tissue diseases, musculoskeletal and connective tissue diseases, Or it is effective in the prevention or treatment of diseases associated with HDAC6 activity including congenital malformations, deformations and chromosomal abnormalities. [Selection figure] None