Anti-AIDS Peptides Inhibit the Interaction of Cell Receptors with HIV

摘要

The present invention provides a peptide that inhibits the interaction of CD4, a cellular receptor, and gp120, an outer membrane protein of human immunodeficiency virus type 1 (hereinafter abbreviated as "HIV-1"), its use, and the peptide. In particular, the screening method is composed of 12 amino acids, amino acid 4 amino acid from the proline (proline), amino acid 6 is phenylalanine (phenylalanine) and the rest of the amino acid peptide as a cell receptor CD4 and The peptide of the present invention, which inhibits the interaction with HIV-1 outer membrane protein gp120, is small enough to be chemically synthesized, yet has an existing acquired immunodeficiency syndrome (abbreviated as "AIDS"). It acts at the early stage of infection of HIV-1 virus, which is completely different from the stage of action of Since membrane specifically inhibiting the interaction of the protein gp120, as well as can be developed into a new AIDS treatment, a peptide that can effectively be used in AIDS therapy by the combined treatment methods to be used in combination with other AIDS therapies. In the present invention, the peptide can be effectively selected using a characteristic panning method using agarose beads.