Prophylaxis and/or treatment of skin inflammatory reactions caused by noxious agents and/or foreign organisms, especially UV radiation, by topical administration of 1-(2-hydroxyphenyl)-alkan-1-one oxime derivative

摘要

The use of 1-(2-hydroxyphenyl)-alkan-1-one oxime derivatives (I) for the prophylaxis and/or treatment of inflammatory reactions of the skin, caused by physical or chemical noxious agents and/or foreign organisms, is new. The use of 1-(2-hydroxyphenyl)-alkan-1-one oxime derivatives of formula (I) for the prophylaxis and/or treatment of inflammatory reactions of the skin, caused by physical or chemical noxious agents and/or foreign organisms, is new. Y, Z' = H, 1-18C alkyl, 2-18C alkenyl, 2-18C carboxyalkyl, 3-18C carboxyalkenyl or 2-18C alkanoyl; R = 1-18C alkyl, 2-18C alkenyl, 3-8C cycloalkyl, aryl, heteroaryl, heteroaralkyl or a fused system, and R1-R4 = H, 1-12C alkyl, 2-12C alkenyl, 1-12C alkoxy, 3-8C cycloalkoxy, aryl, aryloxy, heteroaryl, heteroaryloxy, heteroaralkyl, COOH, OH, Cl, dialkylamino or sulfonyl.