Topical or oral treatment of peach flower extract attenuates UV-induced epidermal thickening matrix metalloproteinase-13 expression and pro-inflammatory cytokine production in hairless mice skin

摘要

BACKGROUND/OBJECTIVESUltraviolet radiation (UV) is a major cause of skin photoaging. Previous studies reported that ethanol extract (PET) of Prunus persica (L.) Batsch flowers (PPF, peach flowers) and its subfractions, particularly the ethylacetate (PEA) and n-butanol extracts (PBT), have potent antioxidant activity and attenuate the UV-induced matrix metalloproteinase (MMP) expression in human skin cells. In this study, we investigated the protective activity of PPF extract against UV-induced photoaging in a mouse model.