Labelable compounds for the simple synthesis of 3 '- 18F fluoro-3'-deoxythymidine and process for their preparation

摘要

The invention relates to compounds, which are suitable for use as labelling precursor substances for producing 3'-[18F]-fluoro-3'-deoxy thymidine and are structured as per formula (1). In said formula, R represents triphenylmethyl, triphenylmethyl substituted on the phenyl group, trialkylmethyl, triphenylsilyl, triphenylsilyl substituted on the phenyl group, or trialkylsilyl; R' represents R1-SO2, whereby R1 stands for an unsubstituted or substituted C1-C5 alkyl or an unsubstituted or substituted phenyl and R" represents a C2-C10 alkyloxy carbonyl, with the exception of 3-N-Boc-1-(3-O-nosyl-5-O-trityl-2 deoxy- beta -D lyxofuranosyl)thymine. The invention also relates to a method for producing said compounds and to the use thereof for synthesising 3'-[18F]-fluoro-3'-deoxy thymidine.