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composition for induction of tumorspezifischen immune response procedures to manufacture and use of the composition for the treatment of neoplasia
composition for induction of tumorspezifischen immune response procedures to manufacture and use of the composition for the treatment of neoplasia
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机译:用于诱导肿瘤特异性免疫应答程序的组合物,以制备和使用该组合物用于治疗肿瘤
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摘要
A composition (I) comprising a phage or functionally equivalent fragment expressing at least one tumor-specific and/or tumor-associated antigen as a fusion protein, with a phage coat protein or derivative on its surface, is new. An Independent claim is also included for a method for the production of (I), comprising: (1) extraction of DNA from an individual tumor cell, so that the gene encoding the tumor-specific antigen can be amplified; (2) cloning, after digestion of the gene in a vector system with restriction enzymes and gel electrophoresis; and (3) expression of the gene as a phage fusion protein.
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