Use of tetrapeptides to promote angiogenesis in treatment of ischemias, lesions, ulcers, and the like and as angiogenesis additives in tissue culture

摘要

Use of tetrapeptides (I) is claimed in medicines to treat pathological disorders that benefit from angiogenesis and as an angiogenesis additive in ex vivo and in vitro tissue cultures. Use of tetrapeptides of formula (I) and their salts is claimed in medicines to treat pathological disorders that benefit from angiogenesis and as an angiogenesis additive in ex vivo and in vitro tissue cultures. A1 = D- or L-Ser; A2 = D- or L-Asp or Glu; A3 = D- or L-Lys, Arg, or Orn; A4 = D- or L-Pro; R1, R2 = H, 1-12C alkyl or 7-20C arylalkyl, both optionally substituted, R4-CO or R4-COO; R4 = 1-12C alkyl or 7-20C arylalkyl (both optionally substituted by OH, NH2 or COOH); X1, X2 = peptidic or pseudopeptidic bonds; X3 = CO or CH2; R3 = OH, NH2, 1-12C alkoxy or NH-X4-CH2-Z, and Z = H, OH, COOH, or CONH2.