Pyrrolidine hydroxamic acid derivatives, useful as metalloprotease inhibitors in the treatment of cancers, rheumatic disorders or neuropathological degenerative disorders, e.g. cerebral ischemia or epilepsy

摘要

Pyrrolidine hydroxamic acid derivatives (I), their optical isomers and salts with acids and bases are new. Pyrrolidine hydroxamic acid derivatives of formula (I), their optical isomers and salts with acids and bases are new. Ar = aryl or heteroaryl; R1 = A, 1-6C alkylene or AXR'1; A = 1-6C alkylene (optionally substituted by one or more OH, 1-6C alkoxy, or 1-6C acyloxy groups); X = O or S; R'1 = H, 1-6C alkyl, aryl 1-6C alkyl or heteroaryl 1-6C alkyl; and R2 , R3, and R4 = H, 1-6C alkyl, or 1-6C alkenyl. An Independent claim is included for the preparation of (I).