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Transgenic animal cell expressing human Fc receptor and humanized immunoglobulin, useful e.g. in screening compounds for antiallergic activity
Transgenic animal cell expressing human Fc receptor and humanized immunoglobulin, useful e.g. in screening compounds for antiallergic activity
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机译:表达人Fc受体和人源化免疫球蛋白的转基因动物细胞,例如筛选化合物的抗过敏活性
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摘要
Transgenic, non-human animal cells (A) express at least one nucleic acid (I) encoding at least one chain (II) of the human receptor for the Fc immunoglobulin (Ig) fragment and a sequence (Ia) encoding the heavy chain (IIa) of an Ig of which at least all or part of Fc is of human origin. The new feature is that the animal gene encoding the chain homologous with (II) is inactivated. Independent claims are also included for the following: (1) transgenic, non-human animals containing at least one (A); in vitro or in vivo methods for detecting an allergen and/or determining its allergic potential; and (2) method of screening compounds that modulate the immediate hypersensitivity response (IHR) and/or inflammation in humans.
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