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Liposomal prodrugs containing camptothecin derivatives and methods of treating cancer using these prodrugs
Liposomal prodrugs containing camptothecin derivatives and methods of treating cancer using these prodrugs
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机译:含有喜树碱衍生物的脂质体前药和使用这些前药治疗癌症的方法
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摘要
Derivatives of camptothecin as represented by the general formula:are described, wherein when R1 is H, R. is a C2-C4 alkyl group, a C6-C15 alkyl group, a C3-C8 cycloalkyl group, a C2-C15 alkenyl group or a C2-C15 epoxy group; and when R2 is a nitro group or an amino group, R1 is a C1-C15 alkyl group, a C1-C15 alkenyl group, a C3-C8 cycloalkyl group, or an epoxy group. Liposomal prodrugs including these specific derivatives of camptothecin restrained by a liposomal delivery system are also described. Processes for making these prodrugs and for using them in cancer treatment are also disclosed.
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