LIPOSOMAL PRODRUGS COMPRISING DERIVATIVES OF CAMPTOTHECIN AND METHODS OF TREATING CANCER USING THESE PRODRUGS

摘要

Derivatives of camptothecin as represented by general formula (I) aredescribed, wherein when R2 is H, R1 is a C2-C4 alkyl group, a C6-C15 alkylgroup, a C3-C8 cycloalkyl group, a C2-C15 alkenyl group or a C2-C15 epoxygroup; and when R2 is a nitro group or an amino group, R1 is a C1-C15 alkylgroup, a C2-C15 alkenyl group, a C3-C8 cycloalkyl group, or an epoxy group.Liposomal prodrugs including these specific derivatives of camptothecinrestrained by a liposomal delivery system are also described. Processes formaking these prodrugs and for using them in cancer treatment are alsodisclosed.