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LIPOSOMAL PRODRUGS COMPRISING DERIVATIVES OF CAMPTOTHECIN AND METHODS OF TREATING CANCER USING THESE PRODRUGS
LIPOSOMAL PRODRUGS COMPRISING DERIVATIVES OF CAMPTOTHECIN AND METHODS OF TREATING CANCER USING THESE PRODRUGS
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机译:包含喜树碱衍生物的脂质体前体药物以及使用这些前体药物治疗癌症的方法
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摘要
Derivatives of camptothecin as represented by the general formula:are described, wherein when R1 is H, R. is a C2-C4 alkyl group, a C6-C15 alkyl group, a C3-C8 cycloalkyl group, a C2-C15 alkenyl group or a C2-C15 epoxy group; and when R2 is a nitro group or an amino group, R1 is a C1-C15 alkyl group, a C1-C15 alkenyl group, a C3-C8 cycloalkyl group, or an epoxy group. Liposomal prodrugs including these specific derivatives of camptothecin restrained by a liposomal delivery system are also described. Processes for making these prodrugs and for using them in cancer treatment are also disclosed.
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