Modified. Alpha. 2,3-sialic acid transferase gene and production of. Alpha. 2,3-sialic acid transferase and sialic acid containing Glycoconjugates

摘要

According to the present invention,. Alpha. 2,3-sialic acid transferases can be produced in large quantities using microorganisms having genes obtained by modifying the base sequence of the. Alpha. 2,3-sialic acid transferase gene derived from microorganisms belonging to the genus Haemophilus. In addition, by contacting the microorganism, CMP NeuAc, and the receptor complex saccharide which produce the enzyme in the aqueous solvent, sialic acid containing glycoconjugates can be produced inexpensively and in large quantities.