Last sterilization bone field characteristic device and its manufacturing

摘要

(57) Last sterilized osteogenic devices for implantation in the [summary] mammal is disclosed. A combination of an insoluble carrier and biologically active osteogenic protein, combined after exposure to ionizing radiation, for example, the device is sterilized by exposure to electron beam or gamma rays. The terminal sterilization device of the present invention, that after transplantation into a mammal, they induce bone formation is characterized. Furthermore, by transplanting the position preselected mammalian terminal sterilization device of the present invention, a method of inducing bone formation in mammals is also disclosed. The methods for preparing the sterilization devices of the present invention is disclosed.