Methods and compositions relating to islets of Langerhans and beta cell dysfunction

摘要

Methods and compositions relating to pancreatic islet and beta -cell dysfunction, in conditions such as non-insulin dependent diabetes, are disclosed. Specifically, proteins that are differentially expressed in these conditions are identified. In one aspect, the invention provides a method of screening an agent to determine its usefulness in treating a condition characterised by pancreatic islet or beta -cell dysfunction, based on establishing a paradigm in which at least one protein is differentially expressed in relevant tissue from, or representative of, subjects having differential levels of pancreatic islet or beta -cell function.