DREBRIN A EXPRESSION-SUPPRESSED ANIMAL NERVE CELL AND NONHUMAN MODEL ANIMAL

摘要

PROBLEM TO BE SOLVED: To provide an animal nerve cell having reduced function of glutamate receptor, and further to provide a nonhuman model animal developing the symptom of schizophrenia, and a method for screening a prophylactic or therapeutic agent by using the animal nerve cell or the nonhuman model animal.;SOLUTION: This animal nerve cell having the regulated function of the glutamate receptor is produced by suppressing the expression of drebrin A by using an antisense oligonucleotide. The nonhuman model animal having the reduced function of the glutamate receptor and developing the symptom of the schizophrenia is produced by administering a drebrin A-expression- inhibiting material such as the antisense oligonucleotide to the nonhuman animal. These animal nerve cell and the model animal can effectively be utilized for the screening of a promoting agent of the function of the glutamate receptor, or the prophylactic or therapeutic agent of the schizophrenia.;COPYRIGHT: (C)2003,JPO