RODENT ANIMAL CELL FOR PRODUCING VIRUS PARTICLE OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1)

摘要

PROBLEM TO BE SOLVED: To provide a culture cell system and a model animal capable of being infected with HIV-1 virus and transcribing and duplicating a virogene. SOLUTION: The rodent animal cells contain human CD4, human kemokine receptor, human CyclinT1 and human CIITA gene in a form which is able to be expressed and are able to produce HIV-virus particles. This method for preparing the rodent animal cells capable of producing HIV-1 virus particles is to introduce human CD4, the human kemokine receptor, human CyclinT1 and the human CIITA gene to the rodent animal cells and infect HIV-1 to the animal cells.