NEW LINEAR OR CYCLIC UREA, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide a medicine useful for the treatment of a disease or a pathological state which is known that the disorder of endothelial function is the cause of the disease and/or the mechanism of worsening the disease because the medicine can limit the disorder of the endothelial function or the reduction of ability for utilizing the blood vessel. SOLUTION: The compound represented by formula (I) [wherein, V is a single bond or the like; M is a single bond or the like; A and E are each a nitrogen atom or the like; R3 is an aryl or a heteroaryl A group which may be substituted as necessary; Y is an aryloxy which may be substituted as necessary or the like], the isomer, the hydrate, the solvate or the addition salt with a pharmaceutically acceptable acid are provided. The pharmaceutical composition containing the compound is also provided.