1. The GAs in two different sites of barbituric acid were estimated by the EKM and using adequate ESI-conditions. 2. The GA values of [1], [2] and [3], deprotonated in nitrogen site are very close among them. 3. The acidity of [1] in α-C5 site is 7 kcal/mol greater than in its N(1) or N(3) site. 4. Experimental GA values are in good agreement with computational ones, obtained at the B3LYP/6-311++G(d,p) level of theory.
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