CD2000 and CD2001 molecules, and uses thereof

摘要

The invention provides isolated nucleic acid molecules, designated CD2000, which encode polypeptide molecules containing Ig and Ig-like domains and SLAM associated protein (SAP) motifs. The invention also provides isolated nucleic acid molecules, designated CD2001, which encode polypeptide molecules containing an Ig and Ig-like domains. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.