Theophylline and 3-isobutyl-1-methylxanthine based N-7 substituted derivatives displaying inhibitory activies on PDE-5 phosphodiesterase

摘要

Compounds of the theophylline and 3-isobutyl-1-methylxanthine (IBMX) based on N-7 substituted derivatives, X being florine, chlorine, bromine or iodine, are provided. These compounds possess pharmacologically inhibitory activities on PDE-5 Phosphodiesterase, relaxation of corpus carvernosal smooth muscle and increase of intracarvernosal pressure (&Dgr;ICP). A process is also provided for the synthesis of some novel theophyline derivatives.