Theophylline and 3-isobutyl-1-methylxanthine based N-7 substituted derivatives displaying inhibitory activities on type five phosphodiesterase

摘要

Theophylline derivative of formula I and II, chemistry chemdraw filechemistry mol file;Wherein R₁ is (CH₂),CH₃; R₂ is a member selected from the group of chemistry chemdraw filechemistry mol file;R₄ is a member selected from the group of H, (CH₂)_nCH₃, X, NH₂ and NO₂; ;R₅ is a member selected from the group of H, chemistry chemdraw filechemistry mol file;wherein R₃ is a member selected from the group of halogen, hydroxyl group (OH), saturated 1-3 straight chain carbon or group substituting one hydrogen; n is 0, 1, 2 or 3. In vivo or in vitro experiments, prove the carvernosal relaxation induced by these compounds.