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Variants of vascular endothelial cell growth factor having altered pharmacological properties, and recombinant methods of production
Variants of vascular endothelial cell growth factor having altered pharmacological properties, and recombinant methods of production
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机译:具有改变的药理特性的血管内皮细胞生长因子的变体以及重组生产方法
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摘要
Described herein are vascular endothelial cell growth factor (VEGF) variants having modifications in the C-terminus heparin binding domain. The variants exhibit reduced clearance rates for systemic administration generally at lower doses compared with native VEGF thus providing variants having longer availability for therapeutic effect.
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