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Variants of vascular endothelial cell growth factor with altered pharmacological properties and related aspects
Variants of vascular endothelial cell growth factor with altered pharmacological properties and related aspects
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机译:具有改变的药理特性的血管内皮细胞生长因子的变体及相关方面
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摘要
Described herein are pharmaceutical compositions including vascular endothelial cell growth factor (VEGF) variants having modifications in the C-terminal heparin binding domain. The variants exhibit reduced clearance rates for systemic administration generally at lower doses compared with native VEGF thus providing variants having longer availability for therapeutic effect.
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