Amide Compounds,Helpful to enhance cholinergic activity, Process for preparing them and Pharmaceutical compositions made with such Compounds, use of these compounds for preparing such compositions and / orPrevent Memory Loss and Dementia and / or method to treat these diseases

摘要

These are amide compounds capable of producing cholinergic activity, and which are useful for treating disorders of the central nervous system. Said compounds have the general formula (1) where R1 is acyl, R2 is lower alkyl, lower alkoxy, lower alkylamino, lower alkenyl, lower alkenyloxy, lower alkenylamino, lower alkynyl, lower alkynyloxy, lower alkynylamino, cycloalkyl (lower),CYCLOPROPYLENE glycol (Times)CricotramineArilo, ariloxi, arilamino, a heteromorphic group or ammonia group replaced by a heteromorphic group, each group can be replaced with appropriate substitutes or acids; a is a simple link, co-o-so2,E is an optional lower tar, replaced by a suitable substitute,X is ch or N, which is a simple link, tar o-nr5 (where R5 is hydrogen, low tar, replaced low tar, an n-protector group, arilo, acilo, or a heterocycle group),This is... This is- I...SO2-O-N=CHR3 and R4 are each kind of hydrogen or lower tar, or combine to form optional lower tar, with a cycle of hydrogen carbon or a heterocyclic ring, if x is n, then (1) is a simple link and Q is - CH2,-O-SO2--(o) (2) it is the lower asphalt and the salt acceptable for the same agent. It also describes the production process of these drugs and the pharmaceutical components containing them, as well as the use of these compounds in drug production.