Method for identifying ligands specific for progesterone receptor isoforms of progesterone Receptors and ligands Selective for Fabrics

摘要

A method to identify specific LIGANDS FOR receptor isoforms of progesterone, as well as a First method to identify Selective progesterone receptor LIGANDS FOR FabricsMethods include selecting LIGANDS FOR isoform Selective progesterone receptor or progesterone receptor isoform B through a test that involves cells stably transfected with plasmids that express the receptor isoforms of progesterone Or B.In addition, it provides a Second method to identify Selective progesterone receptor LIGANDS FOR Fabrics, which comprises tests in vivo in target tissues. It also relates to a ligand specific for progesterone receptor isoforms and / or Selective Tissue identified by the methods according to the present.It is also linked with cell lines suitable for this transactivation Assay, testing equipment, and medical use of ligands specific for progesterone receptor isoforms and / or Selective for tissues.