Compounds derived from 3 - 2 - (phenyl, pyridyl, pirimidil, piridazinil, pirazinil, triazinil pyrimidin-4-yl) - amino - pyrazole,Inhibitors of Protein Kinases Aurora 2 and gsk-3; Intermediate Compounds, Pharmaceutical Composition and use for treating diabetes, Alzheimer's, Schizophrenia, cancer and Lower glucose levels.

摘要

This Invention describes novel pyrazole compounds of formula II: where the phenyl Ring C is selected, pirimidinilo, piridazinilo, pirazinilo pyridinyl, 1.2, or ring,4 - triazinilo, and R2, r2u00b4, RX and ry are as described in the specification. The Ring C has an Ortho Substituent and is optionally substituted in Ortho positions are not.R2 and r2u00b4son optionally taken together with their respective Atoms to form a FUSED Ring System.As a indazolo Ring; and RX and ry are optionally taken together with their respective Atoms to form a FUSED Ring System, as the quinazoline ring.The compounds are useful as inhibitors of Protein Kinases, especially as inhibitors of gsk-3 to treat diseases such as Diabetes and Alzheimer's disease.