An enzymatic process to obtain 4-0-bd-galactopyranosyl-D-xylose, 4-OBD-galato`piranosil-d-xylose obtained according to the procedure, compositions containing it and its use in the evaluation of intestinal lactase.

摘要

Procedure for obtaining compounds of General formula 1, which includes the Racemic mixtures (+ -) - 1, and the enantiomerically Pure compounds (-) and (+) - 1 - 1In which R1 and R3 EQUAL or different, represent a hydrogen Atom, a Methyl Group, Chlorine, Fluorine, trifluoromethyl, ometoxi; R2 represents a hydrogen Atom, Chlorine, Fluorine,A trifluoromethyl Group, methoxy, Methyl, or aminosulfonilo trifluoromethoxy, metilsulfonilo; R4 represents an atom of hydrogen, Chlorine, Fluorine, a Methyl Group,Triflourometilo, methoxy, trifluoromethoxy, metilsulfonilo or aminosulfonilo,Under the condition that one of the substituents R2 or R4 is a Group metilsulfonilo or aminosulfonilo; which includes the obtaining of the racemic mixture of General formula (+ -) - 1.Reaction of a R (e) - 1,1,1 trifluoro - 4 - aryl - - - - - 3 Buten 2 One with PHENYLHYDRAZINE, followed by Treatment with acid clorosulfonico,Or by reaction with acid clorosulfonico followed by reaction with Sodium Hydroxide, and finally with thionyl chloride.The Product obtained by any of these methods aminico is reacted with carbonate or Ammonia or SODIUM SULFITE and methyl iodide and methyl sulfate.On the other hand to get the antiomericamente Pure compounds of General formula I by resolution of the racemic mixture of General formula (+ -) - 1 is a reaction with ephedrineOptically Active, followed by the formation of sodium salt of each one of the enantiomers, reaction with thionyl chloride and carbonate or Ammonia amoico