Aryl substituted pyridinyl, pyrimidinyl, pyrazinyl or triazinyl (VARIANTS) PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT disorders in mammals related to the blockade of sodium channels, METHOD OF TREATMENT, PREVENTION OR REDUCTION OF DIFFERENT INTENSITY disorder or condition METHOD FOR REDUCING INTENSITY OR PROPHYLAXIS Seizures and convulsions in animals

摘要

The present invention relates to aryl-substituted pyridines, pyrimidines, pyrazines and triazines of the formula I or to their pharmaceutically acceptable salts, prodrugs or solvates, with A, A, A, R-R, X and Y defined in the description. The invention also relates to the use of compounds of the formula I for treating neuronal damage in focal or general ischemia, for treating or preventing neurodegenerative conditions, including amyotrophic lateral sclerosis, for treating, preventing or reducing the intensity of acute or chronic pain, as anti-tinnitus, anticonvulsants and anti-manic depressants, as local anesthetics, antiarrhythmics and for the treatment or prevention of diabetic neuropathy. The international search report was published 2002.03.14.