ARYL SUBSTITUTED PYRIDINES, PYRIDINES, PYRAZINES AND TRIAZINES, PHARMACEUTICAL COMPOSITION, METHOD FOR THE TREATMENT OF DISORDERS RESPONSIVE TO THE BLOCKAGE OF SODIUM CHANNELS IN A MAMMAL, METHOD FOR TREATING, PREVENTING OR AMELIORATING OF DIFFERENT CONDITIONS OR DISORDERS, METHOD FOR PREVENTING OR AMELIORATING CONVULSIONS IN A MAMMAL

摘要

This invention relates aryl substituted pyridines, pyrimides, pyrazines and triazines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein A1, A2, A3, R1-R4, X and Y are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhytmics and for the treatment of prevention of diabetic neuropathy.