Aryl-substituted pyrazoles, triazoles or tetrazoles (options), a pharmaceutical composition, a method for treating a disease associated with sodium channel blocking in a mammal, a method for treating, preventing or reducing the intensity of various disorders or conditions, a method for reducing the intensity or prevention of seizures in an animal

摘要

This invention relates to compounds having the Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and RSUB5/SUB-RSUB8 /SUBare set in the specification. The invention also is directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.