SUBSTITUTED IMIDAZOLES AS AN INHIBITORS ACTIVATED FORM ACTIVATED BY THROMBIN INHIBITOR FIBRINOLYSIS (TAFIA)

摘要

The present invention provides compounds of formula (I). These compounds are a class of inhibitors of TAFIa (active Thrombin Activatable Fibrinolysis Inhibitor, an activated form of a thrombin-activated inhibitor of fibrinolysis), atherosclerosis, adhesions, skin scarring, cancer, fibrous conditions, inflammatory diseases, and such conditions in which it is beneficial to maintain or increase bradykinin levels in the body The international application was published along with an international search report.