NMDA RECEPTOR ANTAGONIST 1-(3-HETEROARYL PROPYL- OR-PROP-2-ENYL)-4-BENZYLPIPERIDINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION

摘要

Piperidine derivatives of the formula Iand their physiologically acceptable saltsin which X, Y, Z, R1, R2, R3 and R4 are as defined in claim 1can be as excitatory amino acid antagonists for combating neurodegenerative disorders including cerebrovascular diseases, epilepsy, schizophrenia, Alzheimer's disease, Parkinson's disease and Huntington's disease, cerebral ischaemias, infarcts and psychosis.