PREPARATION OF 5- AND 6-MEMBERED MONOUNSATURATED NITROGEN-CONTAINING HETEROCYCLES FROM PRIMARY AMINES

摘要

A process for the conversion of the nitrogen of a primary amino group of an a, b or a, c hydroxy primary amine into the nitrogen of a monounsaturated nitrogen containing heterocyclic compound having 5 3670 כ" ו בכסלו התשס" ג - December 1, 2002 or 6 atoms in the ring which comprises the sequential steps of (a) treating said hydroxy amine with an excess of a haloaldehyde, wherein the haloaldehyde has the formula: wherein n=2 or 3, Y is CH2, OCH2, or CH2-CH2 X is a halogen, (b) adding an excess, relative to the hydroxyamine, of an organic base, (c) neutralizing the said base with a weak acid, and (d) treating with a dilute aqueous acid.