COMPOSITE BIOMATERIALS FOR PREVENTING POST-SURGICAL ADHESIONS OF TISSUES

摘要

A composite biomaterial for preventing surgical adhesions of tissue comprised of at least one hyaluronic acid derivative selected from the group consisting of: (a) a benzyl ester of hyaluronic acid wherein 75 to 100% of the carboxyl groups of hyaluronic acid are esterified with a benzyl radical and up to 25% of the carboxyl groups are esterified with the alkyl radical of a C10 to C20 aliphatic alcohol, with the proviso that at least 80% of the carboxyl groups are esterified; and (b) an auto-crosslinked derivative of hyaluronic acid wherein 0.5 to 20% of the carboxyl groups of hyaluronic acid are crosslinked to the hydroxyl group of the same or different hyaluronic acid molecule, wherein said biomaterial is in the form of a gel, a membrane or a flat mesh, or a flat woven or non-woven tissue and combinations thereof, and further wherein said biomaterial does not contain either HYAFF7 (100% ethyl ester of hyaluronic acid) or a HYAFF11p75 (75% esterified benzyl ester of hyaluronic acid).